Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by three doses of BNT162b2 vaccine or BA.1 infection3회분의 BNT162b2 백신 또는 BA.1 감염에 의한 Omicron 하위 계통 및 Deltacron SARS-CoV-2 중화Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] Antibody neutralization BNT162b2 BNT162b2 vaccine contribute convalescent sera dose evade geometric mean geometric mean titre geometric mean titres GMT GMTs highest Identifier immune immune evasion individual infected individual infected individuals Infection Mutation neutralization neutralization activity neutralized of BNT162b2 omicron post-dose SARS-CoV-2 SARS-CoV-2 spike sera titre Trial registration unique USA-WA1/2020 vaccinated individual Vaccine variant variants variants. [DOI] 10.1080/22221751.2022.2099305 PMC 바로가기 [Article Type] Article
Efficacy of heterologous boosting against SARS-CoV-2 using a recombinant interferon-armed fusion protein vaccine (V-01): a randomized, double-blind and placebo-controlled phase III trial재조합 인터페론 무장 융합 단백질 백신(V-01)을 사용한 SARS-CoV-2에 대한 이종 부스팅의 효능: 무작위, 이중 맹검 및 위약 대조 3상 시험Clinical Trial Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 임상, 진단, [키워드] adverse event antibody assigned booster clinical trial common adverse event conducted COVID-19 vaccine COVID-19 vaccines dose double-blind dramatic increase Efficacy elicit eligible fatigue Fever fusion protein groups headache healthy Heterologous heterologous boosting Humoral immunity Identifier Immunity inactivated Inactivated vaccine Inactivated Vaccines Inc injection injection site intention-to-treat principle Malaysia Mild-to-moderate Neutralizing Neutralizing antibodies occurred Older omicron Omicron variant over Pain participant Participants Placebo placebo-controlled primary endpoint Randomized Randomly receive regimen robust Safe SARS-CoV-2 SARS-COV-2 infection second dose Serious Adverse Events subunit Subunit vaccine Subunit vaccine. Surveillance symptomatic SARS-CoV-2 infection the epidemic titre Trial Trial registration V-01 Vaccine vaccine efficacy variant virus-neutralizing antibodies was measured were assessed [DOI] 10.1080/22221751.2022.2088406 PMC 바로가기 [Article Type] Clinical Trial
Identification of circulating microRNA profiles associated with pulmonary function and radiologic features in survivors of SARS-CoV-2-induced ARDSSARS-CoV-2에 의해 유발된 ARDS 생존자의 폐 기능 및 방사선학적 특징과 관련된 순환 microRNA 프로파일 식별Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 임상, [키워드] acute respiratory distress syndrome Anti-inflammatory ARDS association carbon monoxide cell death Chest computed tomography circulating Coagulation Complete composed Computed tomography conducted correlated COVID-19 develop diffusing diffusing capacity distress enrichment analyses enrichment analysis evaluated Evidence evidence of feature Features Follow-up Gene ontology genomes hospital discharge hypoxia identification immune response infected patient infected patients KEGG KEGG pathway Kyoto lung Lung function median microRNA miR-126 miR-146 miR-146a-5p miR-21 miR-9 miRNA miRNA profiles miRNA profiling miRNA signature molecular molecular mechanism molecular mechanisms Pathogenesis pathophysiology pathway Patient patients predicted profile provided Pulmonary function radiologic radiological feature radiological features Random forest respiratory distress Respiratory distress syndrome RT-qPCR SARS-COV-2 infection secondary to sequelae severe COVID-19 severity survivor to define total severity score. Trial registration TSS vascularization viral infection was performed was used [DOI] 10.1080/22221751.2022.2081615 PMC 바로가기 [Article Type] Article
The impact of the COVID-19 pandemic on stress and other psychological factors in pregnant women giving birth during the first wave of the pandemicClinical Trial Published on 2022-09-052022-10-05 Journal: Reproductive Health [Category] SARS, 임상, [키워드] acute respiratory syndrome addition Administered affected Analysis Anxiety Anxiety Disorder anxiety level caused clinical collected concern coronavirus correlated correlation Course COVID-19 COVID-19 pandemic Department Depression disease Edinburgh Effect exceptional Factor First wave Germany Gynecology hormone Hospital admission Hospitalization IL-6 impairment increase in interleukin-6 loneliness Maternal Maternal bonding medium mental illness moderate Obstetric pandemic Patient Pregnancy pregnant women Psychological Psychosocial stress questionnaire recruited response resulting SARS-CoV-2 SARS-COV-2 infection scale Self-efficacy self-efficacy. significant increase Sociodemographic Stress stress symptoms Trial registration university women [DOI] 10.1186/s12978-022-01493-9 PMC 바로가기 [Article Type] Clinical Trial
Screening and assessment for post-acute COVID-19 syndrome (PACS), guidance by personal pilots and support with individual digital trainings within intersectoral care: a study protocol of a randomized controlled trial급성 COVID-19 이후 증후군(PACS)에 대한 선별 및 평가, 개인 파일럿의 지도 및 부문 간 치료 내 개별 디지털 교육 지원: 무작위 대조 시험의 연구 프로토콜Article Published on 2022-08-152022-09-11 Journal: BMC Infectious Diseases [Category] SARS, 임상, [키워드] active control group activities activity applicability assigned both group both groups can be used Care chatbot comparability COVID-19 COVID-19 infection Cross-sectoral care Diagnosis Digital Digital therapy offers empowerment Endpoint evaluate evaluated example facilitate feasibility Guidance help helping Identifier IMPROVE Interdisciplinary diagnostic International Intervention intervention group long-COVID Low-threshold screening Medical rehabilitation outcome participant Participants Patient physiological platform Post-acute COVID-19 syndrome Post-COVID primary endpoints propensity score matching Psychological Randomized controlled trial Randomly receive recruited reduce reduction Registration Research return screened Screening secondary Secondary outcomes Study protocol Support supported Symptom Symptom assessment. Symptoms syndrome therapy Treatment Trial registration [DOI] 10.1186/s12879-022-07584-z PMC 바로가기 [Article Type] Article
Local and Systemic Immunity Are Impaired in End-Stage-Renal-Disease Patients Treated With Hemodialysis, Peritoneal Dialysis and Kidney Transplant Recipients Immunized With BNT162b2 Pfizer-BioNTech SARS-CoV-2 VaccineBNT162b2 화이자-바이오엔텍 SARS-CoV-2 백신을 접종한 혈액투석, 복막투석, 신장이식 환자 말기 신장질환 환자의 국소 및 전신 면역 손상Article Published on 2022-07-222022-09-12 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] analyzed anti-S anti-S IgG antibodies antibody binding antibody unit BNT162b2 cellular component clinical control group COVID-19 COVID-19 in patient COVID-19 vaccine dose effective End-stage renal disease ESRD Guidance HD group healthy individual Hemodialysis high mortality rate highest IFN-γ IgA IgG Immunity Immunoglobulin G Impaired Interferon-gamma investigated kidney transplant recipient Local Messenger RNA MONITOR mRNA participant Patient patients performed Peritoneal dialysis Pfizer Pfizer-BioNTech positive produced recipient required Research Responder SARS-CoV-2 Seroconversion seroconversion rate seronegative patient seropositive subjects systemic tested therapy Transplant transplantation. Trial registration Vaccine vaccine response [DOI] 10.3389/fimmu.2022.832924 PMC 바로가기 [Article Type] Article
Persistence of immunity and impact of third dose of inactivated COVID-19 vaccine against emerging variants면역의 지속성과 새로운 변이체에 대한 비활성화된 COVID-19 백신 3차 접종의 영향Clinical Trial Published on 2022-07-142022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), MERS, SARS, 변종, 임상, 진단, 치료기술, 치료법, [키워드] (alpha Alpha Antibody titers B cell memory Beta booster booster dose Breakthrough infection breakthrough infections Cell mediated immunity clinical concern Controlled trial COVID-19 COVID-19 vaccine COVID-19 vaccines D614G Delta dose double-blind Effectiveness Heterologous homologous humoral humoral and cell mediated immunity Immunity immunogenicity inactivated India injection injection site itching magnitude neutralization titer Neutralizing antibodies neutralizing antibody omicron Pain persistence Phase 2 question Randomized controlled trial recipient redness registry responses Safe Serious Adverse Event Serious Adverse Events slight increase strain Trial registration vaccination variant variants VOCs within 6 months [DOI] 10.1038/s41598-022-16097-3 PMC 바로가기 [Article Type] Clinical Trial
Prophylaxis in healthcare workers during a pandemic: a model for a multi-centre international randomised controlled trial using Bayesian analysesRandomized Controlled Trial Published on 2022-06-272022-10-05 Journal: Trials [Category] COVID19(2023년), SARS, 임상, [키워드] acid acquisition acute respiratory syndrome adaptive Admission analysis Bayesian Bayesian analysis Bayesian analysis Bayesian method coronavirus Coronavirus disease 2019 COVID-19 COVID-19 case determine Effect effective Efficacy expected fixed Follow-up futility greater had no hazard ratio HCQ HCW healthcare worker hospitalisation Hydroxychloroquine imperative Infection intensive care International Intervention Ireland less log mechanical ventilation Mortality multicentre New occur occurred Open-label outcome pandemic Pandemics parallel-group participant Pathogens posterior probability Pragmatic primary endpoint proceed Prophylactic Prophylaxis Prophylaxis. randomised randomised controlled trial RCT recruitment reducing reduction in risk Sample size SARS-CoV-2 SARS-COV-2 infection secondary shown Stopping Treatment Trial Trial registration variable [DOI] 10.1186/s13063-022-06402-w PMC 바로가기 [Article Type] Randomized Controlled Trial
Astodrimer sodium antiviral nasal spray for reducing respiratory infections is safe and well tolerated in a randomized controlled trial호흡기 감염 감소를 위한 아스토드리머 나트륨 항바이러스 비강 스프레이는 무작위 대조 시험에서 안전하고 내약성이 우수합니다.Randomized Controlled Trial Published on 2022-06-172022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 임상, 치료기술, 치료제, [키워드] absorbed Absorption Administered administration adverse event All participants Antiviral applied clinical clinical investigation clinical trial clinically Cohort Community community acquired dendrimer double-blinded Effects examination finding examination findings exploratory exposure to followed by four times daily Frequency healthy volunteer help in vitro Infection initial intensity Intensive Mild nasal Nasal cavity nasal mucosa Nasal spray New nostril occurred other respiratory virus Other respiratory viruses participant Placebo placebo-controlled primary endpoint product Randomized Randomized controlled trial receiving reduce reducing Registered registry respiratory infection respiratory virus Respiratory virus infections respiratory viruses Safe safety population SARS-CoV-2 serious AEs severity shown sodium spray Spread systemically TEAE TEAEs Tolerability Treatment Trial registration utility vaginal mucosa Viral load virucidal Withdrawal [DOI] 10.1038/s41598-022-14601-3 PMC 바로가기 [Article Type] Randomized Controlled Trial
Clinical trial registration during COVID-19 and beyond in the African context: what have we learned?아프리카 상황에서 COVID-19 동안과 그 이후의 임상 시험 등록: 우리는 무엇을 배웠습니까?Article Published on 2022-06-062022-09-11 Journal: Trials [Category] 임상, [키워드] activity African change clinical Clinical research clinical trial clinical trial registries collaboration conducted country COVID-19 COVID-19 pandemic COVID-19 research Critical disease Hope impacted indicate Infectious disease Intervention offered outbreak pandemic Perspective poverty principle protocol protocols publication bias Registered Registration registries registry Research researchers Transparency Treatment Trial Trial registration [DOI] 10.1186/s13063-022-06412-8 PMC 바로가기 [Article Type] Article